Research on Hematology, Inflammatory and Antimicrobial Peptide Levels according to Clinical Scoring in Calves with Bovine Respiratory Disease (BRD)

Authors : M Sinan Aktaş, Emre Eren, Ömer Aydın, Kerim Emre Yanar, Sefa Küçükler, Muhammed Sertaç Eroğlu, Şükrü Değirmençay, Murat İlgün

Pages : 196-201

Doi:10.36483/vanvetj.1543947

View : 51 | Download : 26

Publication Date : 2024-11-28

Article Type : Research Paper

Abstract :Bovine respiratory disease (BRD) is a significant and costly disease in cattle, characterized by various infections with distinct causes and clinical signs. This study focuses on investigating some hematological and inflammatory parameters, as well as cathelicidin antimicrobial peptide (CAMP) parameters, in calves with BRD. Forty-two calves were allocated to three groups based on clinical scoring: Group I (n=10, healthy, score 0), Group II (n=16, BRD, score 3), and Group III (n=16, BRD, score 4). Some hematological (WBC, NEU, LYM, NLR, and PLT), inflammatory (IL-1β, TNF-α, NF-ĸB, and IL-10), and CAMP parameters were evaluated in all groups. Group III had significantly higher WBC, NEU, and NLR concentrations than Group I, while concentrations of PLT in Group II were higher than Group I (p<0.05). NF-ĸB, TNF-α, and CAMP levels were enhanced in Group III compared to Group I, and CAMP levels were higher in Group II than in Group I p<0.05). Strong positive correlations were found between NEU and WBC and NLR. Weak positive correlations existed between WBC, NEU, IL-10, and CAMP, as well as between LYM and IL-1β and NF-ĸB and CAMP. In conclusion, the most severe inflammation was observed in Group III, aligning with clinical scoring in BRD-affected calves. CAMP was identified as a reliable marker for inflammation assessment. Additionally, NLR, being low-cost and easily measurable, showed promise as an inflammation indicator.
Keywords : Anti inflamatuar, Sığır Solunum Hastalığı, Buzağı, Cathelicidin antimikrobiyal peptid, Nötrofil Lenfosit Oranı, Pro inflamatuar

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