The clinical characteristics of influenza and other viral respiratory infections in the intensive care unit: A one-year single-center retrospective study

Authors : Volkan Alparslan, Özlem Güler, Samet Kutlu, İpek İzgin Avcı, Aynur Karadenizli, Nur Baykara, Alparslan Kuş
Pages : 212-216
Doi:10.53446/actamednicomedia.1712079
View : 36 | Download : 29
Publication Date : 2025-06-30
Article Type : Research Paper
Abstract :Objective: The aim of this study was to evaluate the clinical features and prognostic factors associated with mortality in respiratory viral infections in intensive care unit patients. Methods: This retrospective, single-centre study included adult patients aged ≥18 years who were admitted to the intensive care unit of Kocaeli University Faculty of Medicine between March 2024 and March 2025 and whose respiratory viral agent was detected by BioFire® Respiratory 2.1 Plus Panel test. Demographic data, clinical and pneumonia scoring systems (APACHE II, SOFA, PSI, CURB-65), laboratory parameters and patient prognosis (survived/non survived) were analysed. Results: A total of 547 out of 2719 intensive care unit patients underwent respiratory panel, and at least one viral agent was detected in 95 (17.4%) of them. The most frequently detected viruses were rhinovirus/enterovirus (n=22), SARS-CoV-2 (n=15) and influenza A-H3 (n=23). The intensive care unit mortality rate was 54.3% in viral positive patients. APACHE II, SOFA, PSI and CURB-65 scores as well as urea and procalcitonin levels were found to be significantly higher in patients with non-survived (p<0.05). Although mortality rates due to viral agents differed according to subgroups, this difference was not statistically significant (p=0.215). Conclusion: Respiratory viral infections in intensive care unit patients are associated with mortality, especially in individuals with high clinical severity scores and some laboratory parameters. These findings need to be confirmed with larger sample, multicentre, prospective studies.
Keywords : Solunum yolu virüsleri, yoğun bakım, influenza, COVID-19, APACHE II, SOFA

ORIGINAL ARTICLE URL