Prognostic Significance of Histopathological and Hematological Markers in Gastrointestinal Stromal Tumors

Authors : Adem Şentürk, Emre Gönüllü, Alp Ömer Cantürk, Ahmet Tarık Harmantepe, Recayi Capoglu, Fuldem Mutlu

Pages : 287-294

Doi:10.53446/actamednicomedia.1677338

View : 40 | Download : 18

Publication Date : 2025-10-22

Article Type : Research Paper

Abstract :Abstract Objective: This study aimed to evaluate the relationship between overall survival and preoperative systemic inflammation and nutritional indices in patients with gastrointestinal stromal tumors (GIST), in addition to conventional histopathological parameters. Methods: In this retrospective study, 43 patients who underwent surgery for GIST were analyzed. Demographic, laboratory, and pathological data were reviewed. Inflammatory and nutritional indices—including HALP, NLR, SII, PNI, and CRP/Albumin—were calculated from preoperative blood parameters. Their effects on 3-year survival were assessed using the Kaplan-Meier method and the log-rank test. Results: High mitotic count and Ki67 index were significantly associated with decreased survival. Patients with elevated RDW levels had significantly shorter survival times (p<0.05). Classification accuracy for HALP, NLR, SII, PNI, and CRP/Albumin was found to be moderate based on their respective cut-off values. Conclusion: This study demonstrates that, in addition to histopathological markers, systemic inflammatory and nutritional indices may serve as useful prognostic tools in GIST patients. These indices could aid in the development of individualized follow-up strategies postoperatively. However, further large-scale prospective studies are warranted to validate these findings.
Keywords : GIST, sistemik inflamasyon, sağkalım, HALP, NLR, PNI, SII, CRP/Albumin, RDW

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