Effect of Sildenafil Citrate on Uterine Artery Doppler Indices in Non-pregnant Rabbits

Authors : Cevdet PEKER, Niyazi KÜÇÜK, Eyüp Hakan UÇAR, Güneş ERDOĞAN

Pages : 685-688

View : 32 | Download : 15

Publication Date : 2020-06-05

Article Type : Research Paper

Abstract :The effect of different doses of sildenafil citrate insert ignore into journalissuearticles values(SC); administrations on arteria insert ignore into journalissuearticles values(a.); uterine blood flow was investigated in healthy female rabbits. Twelve healthy non-pregnant New Zealand rabbits were used in the present study. In the first experimental group insert ignore into journalissuearticles values(n=6);, 5 mg SC thawed in 0.9% NaCl solution was administered orally. Arteria uterina was examined with Pulsed Doppler ultrasonography at pre and post insert ignore into journalissuearticles values(60 minutes); SC administration. Heart rate insert ignore into journalissuearticles values(HR);, pulsatility index insert ignore into journalissuearticles values(PI); and resistance index insert ignore into journalissuearticles values(RI); values were recorded from the a. uterina visualized with cervical channels. Similarly, the study was repeated in second experimental group insert ignore into journalissuearticles values(n=6); by using 10 mg SC for per animal. In the first experiment, the mean HR, PI and RI values were recorded as insert ignore into journalissuearticles values(223 ± 7.80 & 239 ± 15.00);, insert ignore into journalissuearticles values(1.60 ± 0.08 & 1.63 ± 0.16); and insert ignore into journalissuearticles values(0.73 ± 0.02 & 0.73 ± 0.03); before and after SC administration, respectively. In the second experiment, the mean HR, PI and RI values were observed as insert ignore into journalissuearticles values(210 ± 15.00 & 223 ± 14.00);, insert ignore into journalissuearticles values(1.46 ± 0.23 & 1.79 ± 0.08); and insert ignore into journalissuearticles values(0.68 ± 0.05 & 0.77 ± 0.01); before and after SC administration, respectively. No significant difference was between pre and post-administration Doppler parameters in both experiments insert ignore into journalissuearticles values(P>0.05);. Consequently, no enhancing effect on the uterine perfusion was observed in oral 5 and 10 mg SC administrations per rabbit.
Keywords : doppler, uterine artery, sildenafil citrate, rabbit

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