Phytochemical profiling of Brachythecium glareosum (Bruch ex Spruce) Schimp. and preliminary in silico assessment of antifungal potential

Authors : Zafer Çambay, Harun Uslu, Kevser Özdemir Bayçinar, Bünyamin Göktaş, Muhammed Güngören, Mevlüt Alataş

Pages : 44-51

Doi:10.26672/anatolianbryology.1705187

View : 59 | Download : 61

Publication Date : 2025-06-30

Article Type : Research Paper

Abstract :Phytochemical studies show that mosses can produce a range of bioactive chemicals that enhance defense mechanisms and ecological resilience. This study aims to investigate the phytochemical constituents and pharmacological potential of Brachythecium glareosum (Bruch ex Spruce) Schimp. to understand their bioactive potential and to stimulate future research into bryophyte-derived natural products. It also aims to be one of the first studies on B. glareosum in terms of phytochemicals and bioactivity. HPLC analysis revealed the presence of several phenolic compounds in the extract of B. glareosum. The study revealed the in silico antifungal potential of some phenolic compounds. It has been calculated that 2,5-Dihydroxybenzoic acid and 3,4-Dihydroxybenzoic acid compounds will inhibit Cytochrome P450 14Alpha-Sterol Demethylase (Cyp51) of Mycobacterium tuberculosis at the micromolar level. The study suggests that using more advanced methods to analyze B. glareosum could help find more useful compounds that can be used for treatment. Further biological assays are warranted to validate the antifungal activity indicated by in silico predictions.
Keywords : Briyofit, Fitokimyasal, Antifungal Aktivite, Fenolik Bileşikler, In Silico

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