Comparing the effect of insulin infusion alone and in combination of insulin infusion with salbutamol nebulization in treatment of hyperkalemia in diabetic and non-diabetic patients

Authors : Rohit TIWARI, Parmınder NAIN, Jasmine KAUR, Harbir RAO, Jaspreet KAUR

Pages : 412-417

Doi:10.33808/clinexphealthsci.747900

View : 84 | Download : 9

Publication Date : 2021-09-27

Article Type : Research Paper

Abstract :Objective: To evaluate the clinical efficacy and comparison of potassium lowering effect of insulin infusion alone and insulin infusion with salbutamol nebulization. Methods: This interventional study was conducted in a tertiary care hospital, for a period of one year. A total of 190 patients with hyperkalemia were divided into two groups. Group-A insert ignore into journalissuearticles values(diabetic [D] and non-diabetic [ND] patients); received salbutamol 20 mg three times daily insert ignore into journalissuearticles values(TDS); insert ignore into journalissuearticles values(nebulizer 5mg/2.5mL); administered over a period of 15 minutes with 10 units of regular insulin insert ignore into journalissuearticles values(diluted with 25% dextrose in non-diabetic only); over 30 minute TDS via infusion. Group-B insert ignore into journalissuearticles values(diabetic and non-diabetic patients); received 10 units of regular insulin insert ignore into journalissuearticles values(diluted with 25% dextrose in non-diabetic patients only); administered over 30 minute TDS via infusion. Potassium and glucose level was measured in patient blood sample after 0, 6, 12 and 24 hrs of treatment. Results: The potassium level was decreased by 30.09% insert ignore into journalissuearticles values(D); and 31.98% insert ignore into journalissuearticles values(ND); in Group-A, whereas by 31.98% insert ignore into journalissuearticles values(D); and 20.49% insert ignore into journalissuearticles values(ND); in Group-B, after 24 hrs. Whereas blood glucose level in diabetic patients of Group-A and Group-B was found to decrease up to 28.85 % and 40.78 % respectively after 6 hours. Both the treatments were found to be effective without any complication i.e. hypoglycaemia and hypokalaemia. Moreover, renal, liver, cardiac and respiratory function test also did not show significant changes after treatments when recorded bihourly Conclusion: From the results, salbutamol nebulizer with insulin is more effective in the treatment of hyperkalemia in diabetic and non-diabetic patients.
Keywords : Hyperkalemia, Insulin infusion, diabetes, Salbutamol nebulizer

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