CAN HYPO-OSMOTIC SWELLING TEST (HOST) IMPROVE PREGNANCY OUTCOMES IN UNEXPLAINED INFERTILITY PATIENTS WITH NORMAL SEMEN PARAMETERS UNDERGOING ICSI –FROZEN EMBRYO TRANSFER CYCLES?

Ümit ÖZDEMİR; Zafer ATAYURT; Bulat Aytek ŞIK; Özkan ÖZDAMAR; Yılda Arzu ABA; Ozan OZOLCAY

doi:10.33808/clinexphealthsci.852252

CAN HYPO-OSMOTIC SWELLING TEST (HOST) IMPROVE PREGNANCY OUTCOMES IN UNEXPLAINED INFERTILITY PATIENTS WITH NORMAL SEMEN PARAMETERS UNDERGOING ICSI –FROZEN EMBRYO TRANSFER CYCLES?

Authors : Ümit ÖZDEMİR, Zafer ATAYURT, Bulat Aytek ŞIK, Özkan ÖZDAMAR, Yılda Arzu ABA, Ozan OZOLCAY

Pages : 536-541

Doi:10.33808/clinexphealthsci.852252

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Publication Date : 2021-09-27

Article Type : Research Paper

Abstract :Objective: The objective of this study is to compare the pregnancy outcomes of the couples who underwent Hypo-Osmotıc Swelling Test insert ignore into journalissuearticles values(HOST); as a sperm selection method in Intracytoplasmic sperm injection insert ignore into journalissuearticles values(ICSI); – Frozen embryo transfer insert ignore into journalissuearticles values(ET); cycles and those who did not. Methods: ICSI – Frozen ET cycles, employing HOST as a sperm selection method were assigned to the Study Group; whereas those not employing HOST were included in the Control Group. Both study and control groups were divided into two subgroups according to the age of the women; those between the 25-35 years old and those between 36-40. The study and the control group included 509 and 1304 patients; respectively. Patients between 25-40 years old, who received Invitro fertilization insert ignore into journalissuearticles values(IVF); treatment for the first time, had good quality insert ignore into journalissuearticles values(grade A); blastocyst embryo on the 5th day, had normal semen parameters and HOST scores of b, c, and d were included in the study. Results: Pregnancy outcomes were comparable between cycles using HOST and not using HOST in 25-35 years group. However, cycles employing HOST showed significantly higher pregnancy rate insert ignore into journalissuearticles values(p = 0.023);, clinical pregnancy rate insert ignore into journalissuearticles values(p = 0.005);, and live birth rate insert ignore into journalissuearticles values(p = 0.045); as compared to cycles not using HOST, in the 36-40 years group. Conclusion:With normal semen parameters, the use of HOST in ICSI-Frozen ET cycles does not increase live birth rates in women aged 25-35, while it increases the rate of live births in women aged 36-40.
Keywords : Hypo Osmotic Swelling Test, Infertility, Pregnancy Outcomes

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