- Communications Faculty of Sciences University Ankara Series B Chemistry and Chemical Engineering
- Volume:51 Issue:02
- ANTİMİCROBİAL ACTIVITY OF TETRA SUBSTITUTED BENZENE DERİVATİVES
ANTİMİCROBİAL ACTIVITY OF TETRA SUBSTITUTED BENZENE DERİVATİVES
Authors : E LOĞOĞLU
Pages : 0-0
Doi:10.1501/Commub_0000000353
View : 72 | Download : 7
Publication Date : 2005-01-01
Article Type : Research Paper
Abstract :The in vilro antibacterial and antifungal activities of tetrasubstituted benzene derivatives [1-chloro insert ignore into journalissuearticles values(or bromo or iodo);-2,4,6-trichloro and 1-chloro insert ignore into journalissuearticles values(or bromo or iodo);-2, 4,6-tribromo and 1-chloro insert ignore into journalissuearticles values(or bromo or iodo);-2, 4, 6-triiodo benzenes] derived from 2,4,6-trichloro tribromo and triiodo anilines were investigated. Tetrasubstituted benzene dervatives synthesized and identified by spectroscopic means IR and NMR. The antibacterial and antifungal activities were measured by Minumum inhibition concentration insert ignore into journalissuearticles values(MIC); method against gram-positive bacteria i.e. Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 6633; Gram-negative ones as Yersinia enterocolüica ATCC 1501 Escherichia coli ATCC 11230 and fungus as Candida albicans from our strain collection. Antimicrobial activies of these compounds tended to decrease with increasing size of halogene substitutents.Keywords : Antimicrobial activity, Tetra substituted benzene derivatives, MIC, Ampicillin and Fluconazole
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