The Effect of Body Mass Index on the KYN/TRP Pathway in the Pathogenesis of Periodontitis

Home Page
About
Submit A Journal
Submit A Conference
Submit Paper/Book
- Submit a Preprint
- Submit a Book
Contact

European Annals of Dental Sciences
Volume:50 Issue:3
The Effect of Body Mass Index on the KYN/TRP Pathway in the Pathogenesis of Periodontitis

The Effect of Body Mass Index on the KYN/TRP Pathway in the Pathogenesis of Periodontitis

Authors : Zeliha Güney, Sema Merve Altingöz

Pages : 106-111

Doi:10.52037/eads.2023.0025

View : 70 | Download : 81

Publication Date : 2023-12-31

Article Type : Research Paper

Abstract :ABSTRACT Purpose: The tryptophan–kynurenine (TRP-KYN) pathway is associated with inflammation and kynurenine pathway (KP) dysregulation is present in overweight and obesity. Meanwhile, obesity and periodontitis are two of the most frequent noncommunicable illnesses, and epidemiological studies show that obesity has a role in the initiation and progression of periodontitis. However, the association between elevated body mass index and KP on periodontal disease etiology is unknown. As a result, our study is aimed to investigate the possible relationship within TRP/KYN ratio and BMI relationship in periodontitis. Materials & Method: The study comprised 20 periodontitis patients (P, Generalized Stage III Grade B, n=20) and 20 healthy persons (C, n=20). Clinical parameters (Bleeding index on probing (BOP), clinical attachment loss (CAL) and pocket depth (PD)), and BMI were recorded at the beginning of the study. Salivary and serum KYN/TRP ratios were analyzed by using mass spectrometry–liquid chromatography (LC-MS/MS). Results: Clinical periodontal parameters were statistically significantly higher in P group than in C group (p<0.05). While there was no change in serum KYN/TRP ratio across groups, salivary KYN/TRP ratio decreased in Group P compared with Group C (p<0.05). The salivary KYN/TRP ratio was positively correlated with the serum KYN/TRP ratio, while it showed a strong negative correlation with BOP, moderate correlation with PD and CAL, and lower negative correlation with BMI. Conclusion: KP dysregulation due to obesity may increase the risk of developing periodontal disease. Key Words: Periodontitis, Obesity, BMI, KYN/TRP, Tryptophan, Kynurenine
Keywords : Periodontitis, Obesity, BMI, KYN TRP, Tryptophan, Kynurenine

ORIGINAL ARTICLE URL

* There may have been changes in the journal, article,conference, book, preprint etc. informations. Therefore, it would be appropriate to follow the information on the official page of the source. The information here is shared for informational purposes. IAD is not responsible for incorrect or missing information.