Synthesis and Characterization of Gold/Silver Bimetallic Nanoparticles Using Trastuzumab: An Enhanced Anti-Cancer Activity

Authors : Muhammad SAFDAR, Mehmet OZASLAN

Pages : 1-5

Doi:10.55549/epstem.1172660

View : 56 | Download : 8

Publication Date : 2022-09-16

Article Type : Research Paper

Abstract :Bimetallic nanoparticles are getting a lot of attention in medicine and society because they might have interesting physical and synthetic properties, such as higher affinity, a lower molecular weight, and a larger surface area. Trastuzumab capped gold/silver bimetallic nanoparticles insert ignore into journalissuearticles values(Au/Ag-BNPs); were prepared for the purpose of enhancing the effects of Au/Ag-BNPs on SKBR3 breast cancer cells in order to reduce trastuzumab resistance. Au/Ag-BNPs were produced chemically. These Au/Ag-BNPs were characterized using various techniques. UV-Visible insert ignore into journalissuearticles values(UV-Vis); spectroscopy were used to monitor Plasmon absorption maxima at 462 nm. X-ray powder diffraction insert ignore into journalissuearticles values(XRD); pattern was utilized to confirm the crystalline nature of the BNPs. Lastly, Fourier transformed infrared insert ignore into journalissuearticles values(FT-IR); spectroscopy was used to investigate the bonding patterns of the NPs. In SKBR3 human breast cancer cells, the biological characteristics of these NPs were exemplary. Based on the results, we concluded that these gold/silver bimetallic nanoparticles have anticancer potential and can serve as an alternative to decrease the trastuzumab resistance of SKBR3 breast cancer cells. However, additional research is required to corroborate these results.
Keywords : Bimetallic nanoparticles, Trastuzumab resistance, SKBR3 cells, Apoptosis

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