Synthesis of Natural Salicylic Acid as a Cosmetic Ingredient Using Green Chemistry Methods

Authors : Gökhan ÖZOKAN, Tuğba SAĞIR, Ebru EMEKLİ ALTURFAN

Pages : 12-17

Doi:10.26650/experimed.2022.1068934

View : 121 | Download : 17

Publication Date : 2022-03-18

Article Type : Research Paper

Abstract :Objective: Salicylic acid insert ignore into journalissuearticles values(SA); is a keratinolytic agent also used as preservative in cosmetic products. Green chemistry, known as sustainable chemistry, is the design of products and processes eliminating the use of chemicals. It is applicable throughout a chemical product`s life cycle, including its design, manufacture, use, and final disposal. The aim of this study was to synthesize SA with green chemistry methods using different amounts of wintergreen oil and to optimize the relevant steps in this path. Materials and Methods: The SA was synthesized from natural wintergreen oil using green chemistry methods. First laboratory-scale synthesis was developed and 15 laboratory-scale synthesis trial patterns, using reaction temperature, wintergreen oil-sodium hydroxide molar ratio, sodium hydroxide-water weight ratio, reaction time and pH were performed. Purity was analysed with gas chromatography-mass spectrometry insert ignore into journalissuearticles values(GC-MS); and moisture analysis was performed. Results and Conclusion: As a result of pilot production run with 1 kg, 5 kg, and three batches of 20 kg of wintergreen oil, SA was produced with a yield range of 91.06-93.92 %. The resulting SA batches had a purity of approximately 99%. This is a sufficient degree of purity for SA to be used as a raw material in cosmetics products. Filtering the SA solution using a filter press reduced crystal drying time and brought down the total production time to eight days
Keywords : Salicylic acid, Green chemistry, wintergreen oil, cosmetic

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