The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity

Authors : Bertan Boran BAYRAK, Dastagul MAHMARZAYEVA, İsmet Burcu TÜRKYILMAZ, Özlem SAÇAN, Refiye YANARDAĞ

Pages : 38-43

Doi:10.26650/experimed.1085407

View : 35 | Download : 8

Publication Date : 2022-08-22

Article Type : Research Paper

Abstract :Objective: The objective of the current work is to examine the protective effects of S-methyl methionine sulfonium chloride insert ignore into journalissuearticles values(MMSC); on brain in galactosamine insert ignore into journalissuearticles values(GalN);-induced hepatotoxicity in rats. Materials and Methods: A total of twenty two female Sprague-Dawley rats were randomly assigned into four groups as follows: Group I insert ignore into journalissuearticles values(n=5);, intact control animals; Group II insert ignore into journalissuearticles values(n=6);, animals that received 50 mg/kg/day of MMSC by gavage technique for 3 consecutive days; Group III insert ignore into journalissuearticles values(n=5);, animals injected with a single dose of 500 mg/kg of GalN intraperitoneally insert ignore into journalissuearticles values(i.p.);; and Group IV insert ignore into journalissuearticles values(n=6); are animals injected with the same dose of GalN insert ignore into journalissuearticles values(i.p.); 1 hour after MMSC treatment. At the end of the experiments insert ignore into journalissuearticles values(after 6 hours of the last GalN treatment);, all animals were sacrificed under anaesthesia, and brain tissues were dissected out. Results: A statistically remarkable increase in lipid peroxidation, hydroxyproline, and nitric oxide levels, was detected while a notable decline in the activities of sodium/potassium ATPase was observed in GalN group in comparison with control rats. In contrast, all alterations observed were reversed when MMSC was given to GalN groups. Conclusion: Consequently, it may be considered that MMSC has a protective role on brain in GalN-induced hepatotoxicity in rats
Keywords : Galactosamine, S methyl methionine sulfonium chloride, brain, antioxidant effect, oxidative stress

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