Caspase-9 rs1052576 Polymorphism is not Associated with Glioblastoma in Turkish Patients

Authors : Deryanaz BİLLUR, Fatma Tuba AKDENİZ, Seda GÜLEÇ, Zerrin BARUT, Cumhur Kaan YALTIRIK, Turgay İŞBİR

Pages : 108-112

Doi:10.26650/experimed.1183865

View : 32 | Download : 10

Publication Date : 2022-12-31

Article Type : Research Paper

Abstract :Objective: As an aggressive type of brain cancer, glioblastoma remains obscure with its short survival time and unclear molecular architecture. Single nucleotide polymorphisms insert ignore into journalissuearticles values(SNPs);, such as those located in the regions of the caspase-9 gene insert ignore into journalissuearticles values(CASP9);, have been reported to be associated with genetic susceptibility to glioblastoma. There is no exact result on the effect of CASP9 SNP rs1052576 on glioblastoma and its biomarker candidacy for the Turkish population. Investigating the polymorphism of the exon 5 insert ignore into journalissuearticles values(+32 G/A); region of the CASP9 in glioblastoma patients in the Turkish population was the aim of this study. Materials and Methods: Real-time polymerase chain reaction insert ignore into journalissuearticles values(RT-PCR); method on blood samples of glioblastoma patients insert ignore into journalissuearticles values(n=33); and healthy controls insert ignore into journalissuearticles values(n=35); were used to analyze CASP9 SNP rs1052576. Statistical data were obtained using SPSS v.23 software. Results: For CASP9 rs1052576, no evidence was found of its role in glioblastoma insert ignore into journalissuearticles values(p=0.594);. Conclusion: This study was designed to determine the association between glioblastoma and CASP9 SNP rs1052576 within the Turkish population. Our results indicated that CASP9 SNP rs1052576 is not related to glioblastoma in Turkish patients. To clarify these results, further studies with a larger sample size are needed.
Keywords : Caspase9, Glioblastoma, Polymorphism, rs1052576

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