Comparing the VDR Gene BsmI and CDX2Polymorphisms in Healthy Turks and Healthy Somalians Living in Turkiye

Authors : Ender COŞKUNPINAR, Betul Nılgun ENGIN
Pages : 168-173
Doi:10.26650/experimed.1197719
View : 39 | Download : 6
Publication Date : 2022-12-31
Article Type : Research Paper
Abstract :Objectives: This study aimed to evaluate genotypic and allelic differences by comparing the Vitamin D insert ignore into journalissuearticles values(Vit-D); receptor insert ignore into journalissuearticles values(VDR); gene BsmIinsert ignore into journalissuearticles values(rs1544410); and CDX2 insert ignore into journalissuearticles values(rs11568820); polymorphisms in healthy Turks and healthy Somalians living in Turkiye. Materials and Methods: The study involved 100 healthy Turkish individuals and 60 healthy Somali individuals residing in Turkiye for at least 5 years. The genotyping study was performed using the polymerase chain reaction-restriction fragment length polymorphism insert ignore into journalissuearticles values(PCR-RFLP); and allele-specific PCR methods. Statistical analysis was performed to identify the possible differences between groups using the Chi-square and Student’s t tests for pair-wise comparisons. Results: According to the data obtained in the study with regard to the BsmI insert ignore into journalissuearticles values(rs1544410 A/G); and CDX2 insert ignore into journalissuearticles values(rs11568820 A/G); genotypes, no statistically significant difference was determined to be present regarding the frequency of carrying the mutant GG genotype in the two groups insert ignore into journalissuearticles values(p = 0.95 and p = 0.221, respectively);. Conclusion: The study has found no significant genotypic or allelic difference to be present in terms of the BsmI insert ignore into journalissuearticles values(rs1544410); and CDX2insert ignore into journalissuearticles values(rs11568820); gene variants between healthy Turkish individuals and Somali individuals who have spent most of their lives exposed to less sunlight while living in Turkiye for the past five years.
Keywords : VDR, BsmI rs1544410, CDX2 11568820, polymorphism

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