- Experimed
- Volume:13 Issue:1
- Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages
Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages
Authors : D Fulya KIZILGEDİK, Armagan CANER, Çağlar YILDIZ, Buğra OKŞAŞOĞLU, Sema MISIR, İlhan YAYLIM, Semra DEMOKAN, Ceylan HEPOKUR
Pages : 15-20
Doi:10.26650/experimed.1148905
View : 17 | Download : 7
Publication Date : 2023-05-11
Article Type : Research Paper
Abstract :Objective: Endometriosis is a gynecological disease associated with chronic pelvic inflammation, pain, and infertility. Galectin-3 insert ignore into journalissuearticles values(Gal-3); is a protein that can bind to β-galactosides, which plays an important role in different biological processes according to the stages of the disease in patients with endometriosis. This study aimed to elucidate the importance of Gal-3 in endometriosis, to reveal its potential power as a non-invasive diagnostic biomarker in disease etiopathogenesis. Materials and Methods: The serum concentration of Gal-3 and cancer antigen 125 insert ignore into journalissuearticles values(CA-125); from whole blood were measured using enzyme-linked immuno sorbent assay insert ignore into journalissuearticles values(ELISA); and an auto-analyzer, respectively. Gal-3 expression was determined by quantitative real-time polymerase chain reaction insert ignore into journalissuearticles values(qRT-PCR); from peripheral blood. Results: We found significant differences for Gal-3 expression levels between the endometriosis and control groups insert ignore into journalissuearticles values(p <0.05);. Gal-3 levels in the serum of women with endometriosis are also remarkably increased compared with the control group. Conclusion: Galectin-3 can play critical functions in the development and progression of endometriosis, so, further studies are needed in this areaKeywords : Galectin 3, endometriosis, biomarkers, qRT PCR
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