Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population

Authors : Gozde OZCAN, Fatma Tuba AKDENİZ, Seda GÜLEÇ, Zerrin BARUT, Deryanaz BİLLUR, Turgay İSBİR, Cumhur Kaan YALTIRIK
Pages : 54-58
Doi:10.26650/experimed.1232534
View : 32 | Download : 14
Publication Date : 2023-05-11
Article Type : Research Paper
Abstract :Objective: Gliomas are devastating adult brain tumors of unknown etiology, occupying 8 out of 10 primary brain tumors. Epidermal growth factor receptor insert ignore into journalissuearticles values(EGFR); as a tyrosine kinase family member is encoded by the EGFR gene located in chromosome 7p12-13. Various studies have identified numerous SNPs, including those in the EGFR gene, as linked to gliomas. The objective of the investigation was to determine whether the genotype and allele frequencies of the EGFR may have a role in glioma susceptibility. Materials and Methods: To examine the association of EGFR SNP rs1468727 with glioma susceptibility in a case-control study from Türkiye insert ignore into journalissuearticles values(34 cases, 36 controls);, genotyping and statistical analyses were performed by using real-time-polymerase chain reaction insert ignore into journalissuearticles values(RT-PCR); and SPSS version 25.0, respectively. Results: A significant relationship was found between the study groups EGFR SNP rs1468727 genotypes insert ignore into journalissuearticles values(p = 0.028);. The CC genotype frequency was significantly greater in the control group compared to the glioma group insert ignore into journalissuearticles values(p=0.005);. When compared with the control group, the frequency of mutant type T allele carriers was significantly higher in glioma patients insert ignore into journalissuearticles values(p=0.012);. Conclusion: As a result of the preliminary findings, having the mutant T allele may increase risk by 3.36 times, whereas having the ancestral homozygote CC genotype lowers the risk for glioma in Turkish population.
Keywords : Glioma, EGFR Gene, Variation, SNP

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