Long-term effect of intravenous iron carboxymaltose treatment on oxidative stress in women with iron deficiency anemia

Authors : Gökhan PEKTAŞ, İsmail KIRLI
Pages : 3-10
Doi:10.26900/hsq.1.1.02
View : 31 | Download : 3
Publication Date : 2021-04-30
Article Type : Research Paper
Abstract :This study aims to clarify the effects of intravenous iron supplementation on biomarkers for oxidative stress in women with iron deficiency anemia. This is a cross-sectional review of 40 healthy women and 40 women who underwent intravenous iron treatment due to anemia. Biochemical markers for oxidative stress were determined for both healthy controls and anemic patients. These markers were also evaluated at hour 1 and day 30 of intravenous iron treatment. The patients with anemia had significantly higher catalase activity and total oxidant status insert ignore into journalissuearticles values(TOS); but significantly lower nitrate and total anti-oxidant status insert ignore into journalissuearticles values(TAS); than the healthy controls insert ignore into journalissuearticles values(p=0.0245, p<0.0001, p=0.0437 and p<0.0001 respectively);. At hour 1 of intravenous iron treatment, nitrate, nitrite, nitric oxide, total thiol and TAS values were significantly lower and TOS values were significantly higher than those before the administration of treatment insert ignore into journalissuearticles values(p=0.0322, p=0.0003, p=0.0005, p<0.0001, p<0.0001 and p=0.004);. At day 30 of intravenous iron treatment, catalase activity, nitrate, total thiol and TOS values were significantly lower than those before the administration of treatment insert ignore into journalissuearticles values(p=0.0332, p=0.0015, p=0.0391 and p<0.0001 respectively); and at hour 1 of treatment insert ignore into journalissuearticles values(p=0.0498, p<0.0001, p=0.0004 and p<0.0001 respectively);. At day 30 of intravenous iron treatment, nitric oxide and TAS values were significantly higher than those before the administration of treatment insert ignore into journalissuearticles values(p=0.0480 and p=0.001 respectively); and at hour 1 of treatment insert ignore into journalissuearticles values(p<0.0001 for both);. Intravenous iron replacement prompts oxidative stress at hour 1 of infusion in adults with anemia but this increase resolves partially in the following 30 day
Keywords : Anemia, iron, oxidative stress

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