Is there an association between immunohistochemical parameters of breast cancer and metabolic parameters obtained with 18F-fluorodeoxyglucose PET / CT?

Authors : Sadiye ALTUN TUZCU, Ayten GEZİCİ, Bekir TAŞDEMİR, İhsan KAPLAN, Hüseyin BÜYÜKBAYRAM, Feray ALTUN ÇETİN

Pages : 51-61

View : 47 | Download : 10

Publication Date : 2019-12-30

Article Type : Research Paper

Abstract :Introduction: The aim of our study to investigate relationship between 18F -fluorodeoxyglucose PET/CT insert ignore into journalissuearticles values(18F-FDG PET/CT); metabolic parameters and immunohistochemical factors in breast carcinomas. Material and method: Patients with breast carcinomas who underwent 18F-FDG PET/CT imaging at our department between May 2018 and November 2019 were included in this study. A total of 146 female patients were included insert ignore into journalissuearticles values(aged 49.1 ± 13.4years; range, 26-87 years);. PET scanning was performed in 3D mode from the skull ceiling to the middle of the thigh. Metabolic parameters such as TLG insert ignore into journalissuearticles values(Total lesion glycolysis);, MTV insert ignore into journalissuearticles values(Metabolic tumor volume); , SUVmean and SUVmax values were calculated. We obtained the histopathological findings, including the size of invasive cancer, histological type, histological grade, ER and PR status, epidermal growth factor receptor insert ignore into journalissuearticles values(HER2); and Ki-67 of the primary tumor by reviewing the pathology reports. Result: SUV max and SUVmean of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group insert ignore into journalissuearticles values(p=0.009);. SUVmean of progesterone receptor negative group were statistically higher than progesterone receptor positive group insert ignore into journalissuearticles values(p=0.05);. Ki-67 of the Oestrogen receptor negative group and progesterone receptor negative group were statistically higher than Oestrogen receptor and progesterone receptor positive group insert ignore into journalissuearticles values(p=0.001, 0,001 respectively);. Both SUVmax and SUVmean of Ki-67 positive group were statistically higher than Ki-67negative group insert ignore into journalissuearticles values(p=0.0001);. Conclusions: 1-SUV max, SUVmean and Ki-67 of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group. 2-SUVmean and Ki-67 of progesterone receptor negative group were statistically higher than progesteron receptor positive group. 3- HER2 positive and/or triple negative breast cancers were not associated with 18F-FDG PET/CT metabolic parameters
Keywords : breast cancer, Oestrogen receptor, 18F FDG PET CT

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