Changes in the Anterior Segment and Dry Eye Parameters of People Using Oral Tetracycline

Authors : Mehmet Tahir ESKİ, Kuddusi TEBERİK, Taha SEZER

Pages : 309-13

Doi:10.37990/medr.1226595

View : 79 | Download : 10

Publication Date : 2023-05-15

Article Type : Research Paper

Abstract :Aim: The purpose of the study is to evaluate the effect of anti-inflammatory efficiency of tetracycline on dry eye and anterior segment parameters. Material and Methods: This prospective study was conducted with 61 people who had been using tetracycline for the past 2 months. Each participant went through a detailed ophthalmological examination where intraocular pressure insert ignore into journalissuearticles values(IOP);, central cornea thickness insert ignore into journalissuearticles values(CCT);, K1 and K2 from keratometry measurements, anterior chamber depth insert ignore into journalissuearticles values(ACD);, axial length insert ignore into journalissuearticles values(AXL);, tear breakup time test insert ignore into journalissuearticles values(BUT);, lissamin green staining insert ignore into journalissuearticles values(LG);, Schirmer’s tear test-1 insert ignore into journalissuearticles values(ST); and ocular surface disease index insert ignore into journalissuearticles values(OSDI); score were evaluated. Measurements of the patients who would be using a daily dose of 100 mg doxycycline for 2 months were done prior to the medication as well as 1 month and 2 months after the medication. 3 data sets of the participants were compared at the end of 2 months. Results: When results were compared, it was found that ST and LG parameters gradually increased in the first and second months and this increase was statistically significant insert ignore into journalissuearticles values(p<0.001 and p=0.018, respectively);. On the other hand, BUT and OSDI scores decreased over time but it was not statistically significant. There were no statistically significant differences in terms of other parameters either insert ignore into journalissuearticles values(p>0.05);. When female and male participants were compared in terms of BUT, it was found that the decrease in females at the second month was higher and this was statistically significant insert ignore into journalissuearticles values(p=0.01);. Conclusion: t was concluded that the young individuals using tetracycline displayed an early stage of improvement in dry eye parameters.
Keywords : Dry eye, tetracycline, anterior segment

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