Is Serum Tryptase a Dependable Biomarker for Diagnosing and Tracking Rheumatoid Arthritis?

Authors : Mehmet Serhat Topaloğlu, Gül Devrimsel, Ayşegül Küçükali Türkyılmaz, Aynur Kırbaş, Hacer Bilgin Topaloğlu, Münevver Serdaroğlu Beyazal, Murat Yıldırım

Pages : 370-376

Doi:10.37990/medr.1629318

View : 132 | Download : 86

Publication Date : 2025-05-09

Article Type : Research Paper

Abstract :Aim: Our aim in this study was to demonstrate that rheumatoid arthritis (RA) patients have an increase in serum tryptase concentrations and that this correlates with the level of disease activity. Material and Method: The research involved 43 patients RA and 37 healthy participants as the control group. The average ages of the patients and the control group were 52.53±11.10 and 48.41±12.79 years, respectively. Sociodemographic information of all participants was recorded. Disease Activity Score 28 (DAS28), Health Assessment Questionnaire (HAQ) and Visual Analog Scale (VAS) scores were calculated after detailed examination to determine disease activity. Total serum tryptase concentrations were evaluated using enzyme-linked immunosorbent assay (ELISA). Results: Serum tryptase levels were higher in the RA group compared to the healthy group and a statistically significant difference was found (p 0.05). Conclusion: The findings reveal that serum tryptase levels are upregulated in subjects with RA and demonstrate a correlation with disease activity. Serum tryptase may contribute to inflammation in RA.
Keywords : Biomarker, diagnosing, rheumatoid arthritis, serum tryptase

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