The Renoprotective Effects of Desflurane And Sevoflurane in Lower Limb Ischemia-Reperfusion Injury on Streptozotocin-Induced Diabetic Rats

Authors : Muhammed Enes AYDIN, Şaban Cem SEZEN, Mustafa ARSLAN, Meral ERDAL, Mustafa KAVUTCU

Pages : 75-82

View : 70 | Download : 14

Publication Date : 2021-01-25

Article Type : Research Paper

Abstract :Aim: The study aims to determine the protective effects of sevoflurane and desflurane on the kidneys in lower limb ischemia-reperfusion injury insert ignore into journalissuearticles values(IRI); streptozotocin-induced diabetic rats. Method: Thirty Wistar rats were randomly divided into equal five groups. The control insert ignore into journalissuearticles values(group C);, diabetes-control insert ignore into journalissuearticles values(group DC);, Diabetes-I/R insert ignore into journalissuearticles values(group DIR);, Diabetes-I/R-sevoflurane insert ignore into journalissuearticles values(group DIRS);, Diabetes-I/R-desflurane insert ignore into journalissuearticles values(group DIRD);. 55 mg/kg Streptozotocin was administered intraperitoneally to diabetic groups as a single dose. 72nd hours were considered diabetic blood glucose 250 mg/dl or above, and at the end of 4 weeks, all groups underwent laparotomy. In groups C and DC, there was no further action. In the group, DIR was performed 2 hours in the infrarenal abdominal aorta in order clamped be put and remove. Sevoflurane and desflurane were administered so that the minimum alveolar concentration was one during the ischemia and reperfusion periods. At the end of the reperfusion period, kidney tissues were taken for biochemical and histopathological examinations. Results: In the DIR group, Nitric oxide synthases insert ignore into journalissuearticles values(NOS); enzyme activity was observed significantly higher than C and DC groups. In DIRS and DIRD groups, it was significantly lower than DIR. TBARS level is significantly higher in all groups compared to group C. In the DIR group, it was significantly higher than in the DC group. In DIRS and DIRD groups, it was significantly lower than DIR. DIR group Superoxide dismutase insert ignore into journalissuearticles values(SOD); enzyme activity was observed significantly higher than C and DC groups. In DIRS and DIRD groups, it was significantly lower than DIR. Conclusion: These results demonstrate that sevoflurane and desflurane have protective effects on the kidneys in lower limb IRI on streptozotocin-induced diabetic rats.
Keywords : Ischemia reperfusion, sevoflurane, desflurane, kidney

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