The relationship between plasma fibrinogen levels and mortality in patients with sepsis followed in the intensive care unit

Authors : Oktay İnan, Ezgi Aydın İnan, Engin İhsan Turan, Semih Çelik, Emirhan Kahraman, Alican Ruşen, Merve İkbal Göncü, Ebru Kaya, Ayça Sultan Şahin

Pages : 1-6

Doi:10.54270/atljm.2026.102

View : 83 | Download : 192

Publication Date : 2026-02-27

Article Type : Research Paper

Abstract :Introduction: Sepsis is a clinical picture closely associated with mortality that affects a large number of patients worldwide every year. This condition, which is frequently associated with infection, can also develop due to noninfectious causes such as burns. Sepsis is also associated with disseminated intravascular coagulation (DIC). Fibrinogen is a coagulation factor secreted from the liver. Liver failure, cardiac diseases, malignancies and some chemotherapy drugs may affect fibrinogen levels. Especially fibrinogen tends to decrease due to sepsis. This is of critical importance especially in sepsis-associated DIC. Material and method: In this retrospective study of 80 patients aged 18-90 years who were hospitalized in the anesthesiology and reanimation intensive care unit, fibrinogen, platelet, WBC, INR, aPTT, CRP, procalcitonin, SOFA and ISTH scores measured on days 0 and 3 were collected and their relationships with mortality were compared. Statistical analyses were performed using SPSS 22.0 for. Patients were divided into 3 groups according to fibrinogen trend. Results: According to statistical analysis, SOFA and ISTH scores were found to be high in the group with low fibrinogen level (p:0,032 - p:0,005 for SOFA, p:0,026 - p:0,038 for ISTH score, respectively), and WBC, Platelet, Procalcitonin and D-Dimer were found to be high among laboratory parameters (p: 0.013 - p:0.020 for WBC, p:0.030 for Platelet, p:0.009 - p:0.008 for Procalcitonin, p:0.001 - p:0.008 for D-Dimer, respectively) and mortality was higher in the group with decreased fibrinogen level compared to the other groups (p<0.001). Discussion: In sepsis and DIC, it is critical to rapidly diagnose, initiate treatment and predict mortality. Although many scoring systems have been developed for this purpose, SOFA is the most commonly used scoring system for sepsis and ISTH for DIC. According to our results, SOFA and ISTH scoring systems as well as decreased fibrinogen level can be used to predict mortality. Decreased fibrinogen level in sepsis can be used as a predictor of mortality.
Keywords : dissemine intravascular coagulation, sepsis, koagülasyon, fibrinojen

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