RELATIONSHIP OF NEURON SPECIFIC ENOLASE LEVELS IN SERUM AND CEREBRO SPINAL FLUID WITH COMPLICATIONS AND CLINICAL FOLLOW-UP IN PATIENTS WITH ACUTE BACTERIAL MENINGITIS

Authors : Şadan Hacısalihoğlu, Ahmet Alver, Murat Topbaş, Süleyman Karahan, Abdurrahman Avar Özdemir, Fatma Müjgan Sönmez
Pages : 195-203
Doi:10.54270/atljm.2025.100
View : 95 | Download : 407
Publication Date : 2025-10-29
Article Type : Research Paper
Abstract :Objective: Our aim in this study is to investigate the relationship between serum CRP levels and cerebrospinal fluid and blood Neuron-specific enolase (NSE) levels in patients with bacterial meningitis. Materials and Methods: This study was conducted on 22 patients treated with a diagnosis of acute bacterial meningitis. The diagnosis of meningitis was made based on patient history, clinical and laboratory findings. Lumbar puncture was performed on patients at the initial presentation, on days 1 and 7, and on days 15 and 21 if recovery was not observed. The collected samples were analyzed for cell count, culture, Wright and Giemsa staining, protein, and glucose levels. Clinical scoring was performed for all patients at the specified time points. Findings: With treatment, a significant decrease in cerebrospinal fluid protein levels and leukocyte count was observed on days 1 and 7, while clinical scores and glucose levels showed an increase (p<0.05). A positive correlation was observed between cerebrospinal fluid NSE levels and serum CRP values measured at baseline and day 1. However, no correlation was found between serum NSE and CRP or cerebrospinal fluid NSE levels. Four patients developed complication had lower glucose, CRP, and cerebrospinal fluid NSE levels but higher protein and leukocyte counts compared to the other patients. No significant difference was found in serum NSE levels (p>0.05). Conclusion: Cerebrospinal fluid and serum NSE levels change with neuronal damage in patients with bacterial meningitis, but no relationship was found between NSE levels and duration of treatment and development of complications.
Keywords : Akut bakteriyel menenjit, Çocuk, Nöron spesifik enolaz

ORIGINAL ARTICLE URL