Obstrüktif Uyku Apne Sendromu OUAS Saptanan Hastalarda Vasküler Fonksiyon Bozukluğu ve Ateroskleroz Riskinin Değerlendirilmesi

Authors : Elçin AYDIN, Cihan ALTIN, Birsen ŞAHİN SATILMIŞ, Erkan EŞKİ, Mustafa Agah TEKİNDAL, Muhteşem AĞILDERE

Pages : 627-633

View : 80 | Download : 15

Publication Date : 2019-12-01

Article Type : Research Paper

Abstract :Purpose: To investigate endothelial dysfunction and pre-atherosclerosis in patients with Obstructive Sleep Apnea Syndrome OSAS by using several parameters including Brachial Artery Flow-Mediated Vasodilation BAFMV , Carotid Intima-Media Thickness CIMT , Mean Platelet Volume MPV and Epicardial Fat Thickness EFT . Patients with OSAS were classified according to the Apnea-Hypopnea Index AHI . Patients and Methods: OSAS patients who have 5 or more AHI score were enrolled in the study. Patients with hypertension, hyperlipidemia, diabetes mellitus and cardiovascular diseases were excluded. Patients were classified as mild 5-10 , moderate 16-30 and severe >30 according to AHI. These groups were compared to each other in terms of endothelial dysfunction and pre-atherosclerosis markers including BAFMV, CIMT, MPV and EFT. Groups were compared statistically by using either Student’s T-Test or Mann Whitney–U test. Results: Our study population consists of 23 patients with OSAS 16 male, 7 female with the mean age of 46.30±9.51 years ranging from 31-65 years. There were no significant differences in all parameters between the mild 5-10 , moderate 16-30 and severe >30 groups according to AHI. Conclusion: It is well known that patients with OSAS have an increased cardiovascular risk. In our study, no differences were shown between the progression of the disease and endothelial dysfunction and pre-atherosclerosis markers.
Keywords : Endothelial dysfunction, pre atherosclerosis, obstructive sleep apnea syndrome

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