Efficacy of Taxifolin in The Prevention of Renal Injury Due to Liver Ischemia and Reperfusion

Authors : Burak Veli Ülger, Fırat Aşir, Metin Varli, Ercan Gündüz, Hasan Mansur Durgun

Pages : 503-507

Doi:10.36516/jocass.1371823

View : 46 | Download : 64

Publication Date : 2023-12-31

Article Type : Research Paper

Abstract :Aim: During surgical procedures such as liver resection and transplantation, ischemia/reperfusion (I/R) injury and related complications may occur at a rate of approximately 10%. Our study, we planned to investigate histologically and biochemically the efficacy of Taxifolin in the prevention of renal tissue damage in liver ischemia reperfusion. Methods: A total of 28 Wistar Albino rats with an average age of 8-10 weeks and weights of 250-300 grams were used in our study. Group 1 (n=7): control group, Group 2 (n=7): Taxifolin group; Taxifolin was administered orally at a dose of 50 mg/kg for 3 weeks, Group 3 (n=7): Liver I/R group, 30 minutes ischemia and 120 minutes reperfusion was performed. Group 4 (n=7): Taxifolin+Liver I/R group. Results: Kidney tissues of the liver I/R group showed atrophy, degeneration of tubule epithelium and increased TNF-α expression. In addition, deterioration in renal function tests was also monitored in this group. In the Taxifolin+Liver I/R group, a significant difference was observed on both histologic and biochemical basis compared to the Liver I/R group and a positive effect was observed (p<0.05). Outcome: As a consequence of hepatic ischemia and reperfusion, impairment in the function and histological appearance of renal tissues was observed and Taxifolin was monitored to be effective in eliminating these adverse effects.
Keywords : Karaciğer iskemi ve reperfüzyon, Taksifolin, Histopatoloji, İmmunohistokimya, Oksidatif stres

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