Localized Amyloidosis in Basal Cell Carcinoma: A Single-Center Experience

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Localized Amyloidosis in Basal Cell Carcinoma: A Single-Center Experience

Localized Amyloidosis in Basal Cell Carcinoma: A Single-Center Experience

Authors : Şeyhmus Kaya, Şuranur Güler, Hatice Reyhan Eğilmez, Ramazan Oğuz Yüceer

Pages : 811-819

Doi:10.5798/dicletip.1841068

View : 26 | Download : 64

Publication Date : 2025-12-12

Article Type : Research Paper

Abstract :Objective: Basal cell carcinoma (BCC) is the most common skin cancer. In the literature, studies investigating amyloid deposition in this tumor are limited. This study aimed to evaluate the frequency of amyloid deposition using histochemical Congo red staining in BCC cases and to analyze its association with clinicopathological parameters. Methods: A total of 243 patients with histopathologically confirmed BCC who had excisional biopsy specimens between January 1, 2022, and November 30, 2024, were included from the pathology archives. The presence of amyloid was assessed by Congo red staining and confirmed by apple-green birefringence under polarized light microscopy. Results: The mean age of the patients was 64.0±13.3 years, and 58.4% were male. The most frequent tumor localization was the head and neck region (78.2%). Histologically, the nodular subtype was the most common (91.4%). Amyloid deposition was detected in 26.3% of cases, exclusively in the nodular subtype. Amyloid positivity was significantly higher in the older age group (p = 0.003). Moreover, a significant association was observed with higher Clark level (p < 0.001) and recurrence (p = 0.045), whereas no significant correlation was found with sex, localization, ulceration, or peritumoral inflammation. Conclusion: This study demonstrated that amyloid deposition in BCC may be associated with certain clinicopathological parameters. The findings suggest that amyloid deposition may not only represent a histopathological feature but also a potential prognostic marker. Larger prospective studies incorporating immunohistochemical analyses are needed to better elucidate this relationship.
Keywords : Bazal hücreli karsinom, amiloid, lokalize deri amiloidozu, Kongo red

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