Independent Association Between Paraoxonase 1 and Pulmonary Pulse Transit Time in Patients Undergoing Hemodialysis

Authors : Kağan Tur, Aydın Güçlü, Kenan Güçlü
Pages : 49-61
Doi:10.56728/dustad.1662717
View : 26 | Download : 13
Publication Date : 2025-06-26
Article Type : Research Paper
Abstract :Pulmonary hypertension (PH) and pulmonary fibrosis are significant complications of hemodialysis. Pulmonary pulse transit time (pPTT) is a valuable non-invasive marker for assessing these conditions. Paraoxonase 1 (PON1) has strong antioxidant and anti-inflammatory properties, making it effective in combatting oxidative stress and inflammation. Its effectiveness in these areas suggests that it may be associated with echocardiographic parameters in hemodialysis patients. This study examines the correlation between PON1 and echocardiographic parameters in this specific patient group. The study included a total of 36 patients receiving maintenance hemodialysis for at least three months were included in this study. Blood samples and echocardiographic assessments were obtained before and after the hemodialysis sessions. The mean age of the participants was 59.3 ± 13.27 years, with an average hemodialysis duration of 6.2 ± 5.5 years. Post-hemodialysis PON1 activity was significantly higher than pre-hemodialysis levels (r = 0.967, p < 0.0001). Negative correlations were observed between post-hemodialysis PON1 and post-hemodialysis pPTT (r = -0.410, p = 0.009), between pre-hemodialysis PON1 and pre-hemodialysis pPTT (r = -0.381, p = 0.014). Additionally, post-hemodialysis PON1 was positively correlated with post-hemodialysis early diastolic mitral annular velocity (E\\\') (r = 0.345, p = 0.050). Multiple linear regression analysis revealed that pPTT (p < 0.05) was a statistically significant predictor of PON1 activity, while C- Reactive Protein (CRP) (p = 0.055) approached statistical significance (R = 0.527, p < 0.05). This study is the first to report an independent association between Pptt, an indicator of pulmonary hypertension (PH) and pulmonary fibrosis—and PON1 activity in hemodialysis patients. These findings suggest that PON1 may play a role in the pathophysiology of pulmonary complications in this population.
Keywords : hemodiyaliz, pulmoner hipertansiyon, pulmoner fibrozis, paraoksonaz 1, kronik böbrek hastalığı

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