Effects of Botulinum Toxin a Treatment on Ocular Surface in Patients with Entropion

Authors : Mehmet Can Özen, Murat Oklar, Mustafa Talan, Titap Yazıcıoğlu, Şaban Şimşek

Pages : 71-81

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Publication Date : 2025-08-28

Article Type : Research Paper

Abstract :OBJECTIVE: This study aims to investigate the effects of Botulinum toxin A (BTA) and surgical intervention on the ocular surface in patients with entropion. MATERIALS and METHODS: This is a prospective case-control study. The patients who have entropion (senile and spastic) are treated with BTA or surgical operation (Jones Procedure). Tear break up time (TBUT), ocular surface disease index (OSDI) score, Schirmer I test, and Oxford scale were analyzed at the outset and one and three months after the procedure. RESULTS: Fifty patients (23 males, 27 females; mean age 65.04 ± 6.97 years) participated in the study. Significant improvements were observed in TBUT, OSDI, Schirmer I, and Oxford scores after both BTA and surgery. No difference was found in TBUT between the first and third month. OSDI scores were significantly lower in the group at both time points (p=0.039, p=0.049). Schirmer I was higher in the surgery group at the third month (p=0.040), while the BTA group had lower Oxford scores at the first month (p=0.037), with no difference at the third month. CONCLUSION: BTA application is an effective and safe method to improve ocular surface parameters in the treatment of entropion. The fact that some of these effects are superior to the surgical method may cause BTA application to be preferred in patients with ocular surface disorders.
Keywords : Botilinum Toksin A, Entropiyon, Göz Kapağı, Ön Segment

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