APTAMER-BASED ELECTROCHEMICAL SENSORS FOR ILLICIT DRUG DETECTION: FORENSIC APPLICATIONS IN THE LAST DECADE YEARS

Authors : Ezgi Emen, Fatma Nil Ersoy Ertaş, Pınar Kara Kadayıfçılar, Serap Akgur

Pages : 505-520

Doi:10.18185/erzifbed.1616754

View : 65 | Download : 128

Publication Date : 2025-08-31

Article Type : Review Paper

Abstract :Illicit drugs are a global problem, and a variety of selective techniques are urgently needed to detect drugs of interest. Biosensors are integrated devices that combine biological recognition elements with transducers. Aptasensors are aptamer-based affinity biosensors, which are known for their exceptional specificity and high binding affinity to target molecules, and are providing significant advancements in the field of health, food, environmental, and forensic applications. Many aptasensors are nearly identical to conventional immunochemical aptamer, and aptamers are analogous to antibodies. Electrochemical aptasensors are aptamer for biological recognition integrated with electrochemical transduction. Recent studies on the use of electrochemical aptasensors for the detection of illicit drugs, including cannabis, opioids and amphetamine derivatives, in the last decade are discussed in this section. This section aims to present current technologies and challenges, and highlights gaps in the literature that can be addressed. This review emphasises the need for further research and development to improve the sensitivity, selectivity and applicability of aptasensors for point-of-care applications.
Keywords : Yasadışı maddelerin analizi, Aptamer, Elektrokimyasal aptasensörler, biyolojik matris, kokain

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