The Effects of Garlic Extracts on Prostate Cancer

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Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi
Cilt: 18 Sayı: 3
The Effects of Garlic Extracts on Prostate Cancer

The Effects of Garlic Extracts on Prostate Cancer

Authors : Furkan Kuznek, Recep İlhan, Gökçe Yıldırım Buharalıoğlu, Ahmet Emir

Pages : 781-788

View : 93 | Download : 152

Publication Date : 2025-12-31

Article Type : Research Paper

Abstract :In the current study, garlic samples obtained from various provinces of Turkey, including Kastamonu, Balikesir, Edirne, and Aksaray, were analyzed for their chemical composition and biological activity. The organosulfur content of the prepared extracts was assessed using GC-MS. A total of seven compounds were identified across all samples, with 3-Vinyl-4H-1,2-dithiin and 2-Vinyl-4H-1,3-dithiin recognised as the predominant compounds. Additionally, the effects of these extracts on benign prostatic hyperplasia (BPH), as well as on the LNCaP, DU145, and PC3 cell lines, were evaluated using MTT assays. Cytotoxic activity was detected in all samples examined. The most pronounced activity was recorded against the LNCaP cell lines, exhibiting varying IC50 values ranging from 23.91 to 48.84 µg/ml.
Keywords : Sarımsak, Organosülfür bileşikleri, Prostat kanseri

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