Development of Innovative Microemulsion-based Gelatine Capsules of Ondansetron Hydrochloride

Authors : Sreehari Nair, Dhanashree Sanap, Kisan Jadhav

Pages : 319-328

Doi:10.55262/fabadeczacilik.1594125

View : 25 | Download : 28

Publication Date : 2025-08-26

Article Type : Research Paper

Abstract :This research investigates the formulation and assessment of gelatine capsules containing a microemulsion of ODN aimed at improving its bioavailability and therapeutic effectiveness. ODN a commonly utilized antiemetic, is characterized by low oral bioavailability primarily due to significant first-pass metabolism. To mitigate this challenge, a microemulsion system was developed utilizing a blend of oil, surfactant, and co-surfactant, which was subsequently encapsulated within gelatine capsules. The resulting capsules were analysed for their drug excipient interactions, drug release profile etc, ensuring that the formulation possessed optimal characteristics for enhanced drug delivery. Findings indicated that the microemulsion-based gelatine capsules markedly enhanced the dissolution rate of ODN, indicating a viable strategy for addressing its bioavailability challenges. This study presents an innovative formulation approach that holds potential for improving the therapeutic efficacy of ODN in clinical applications.
Keywords : Microemulsion, Ondansetron hydrochloride, Gelatine capsule, spectroscopy, quality control

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