Synthesis of Some Benzothiazolone Derivatives and Their Effects On Quorum Sensing

Authors : Yasemin Dündar, Meryem Burcu Külahcı, Özge Kuyrukçu Öztürk, Ebru Beyzi

Pages : 721-732

Doi:10.55262/fabadeczacilik.1787503

View : 52 | Download : 117

Publication Date : 2025-10-30

Article Type : Research Paper

Abstract :Quorum sensing (QS), which enables bacteria to communicate by sensing their population density and, in particular, to regulate biofilm formation and virulence factor production in pathogenic bacteria, has emerged as a novel target for the control of bacterial infections. In this study, the QS inhibitory effects of benzothiazolone and its nitrogen-substituted derivatives were investigated. For this purpose, the effects of the synthesized compounds on violacein production by Chromobacterium violaceum, inhibition and eradication of biofilm formed by Pseudomonas aeruginosa, inhibition of proteolytic activity, and their influence on bacterial swimming and swarming motilities were examined. Among the synthesized compounds, benzothiazolone (Q1) and N-acetylbenzothiazolone (Q8) were determined to be the most active QS inhibitors, particularly with their effects on pigment and biofilm inhibition. Benzothiazolone derivative QS inhibitor compounds may serve as lead compounds for future studies.
Keywords : antibakteriyal aktivite, benzotiyazolon, çoğunluk algılama inhibitörleri.

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