Effect of Pomegranate Seed Oil and Punicic Acid on Alzheimer’s Disease

Authors : Zehra Şen, Havvanur Yoldaş İlktaç

Pages : 107-120

Doi:10.56061/fbujohs.1552078

View : 89 | Download : 42

Publication Date : 2025-04-30

Article Type : Review Paper

Abstract :Alzheimer\\\'s disease is a neurodegenerative disease and is one of the most common forms of senile dementia observed in the elderly population. It is estimated that the number of individuals affected by Alzheimer\\\'s disease will reach 115.4 million by 2050. It is imperative that novel and alternative methods be developed to prevent and slow the onset of Alzheimer\\\'s disease, as well as to alleviate the symptoms that manifest subsequent to its onset. Given the pivotal role of oxidative damage and inflammation in the pathogenesis of Alzheimer\\\'s disease, there is a growing interest in phytochemicals with high antioxidant and anti-inflammatory properties as potential therapeutic agents for halting disease progression. The anti-inflammatory, antioxidant and neuroprotective properties of pomegranate seeds and punisic acid (the omega-5 isomer of conjugated linoleic acid, the main component of pomegranate seeds) are hypothesised to be an effective method of reducing the occurrence and symptoms of Alzheimer\\\'s and neurodegenerative diseases. This review examines the impact of pomegranate seed oil and punisic acid on Alzheimer\\\'s disease.
Keywords : Alzheimer hastalığı, anti-inflamatuar, nar çekirdeği yağı, nöroprotektif, punisik asit

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