Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler

Authors : Sahra Setenay BARAN, Belma ASLIM

Pages : 36-50

Doi:10.5281/zenodo.4317954

View : 57 | Download : 10

Publication Date : 2020-12-30

Article Type : Review Paper

Abstract :Neurodegenerative disorders are results of structural and functional dysfunction of the nervous system. Although there are several therapeutic approaches for these diseases, these approaches cannot be effective in pathological processes and are applied only palliative. For this reason, new compounds for neurodegenerative diseases are crucial. Calcium (Ca2+) which acts as a second messenger, is required for neuronal activity as well as for many biological activities. The pivotal role of Ca2+ homeostasis has long been recognized in hypertension and cardiovascular disease. Ca2+ channel blockers have been commonly prescribed for treatment of the hypertension and cardiovascular diseases because of their mechanism of action due to reducing the influx of Ca2+ . Disruptions in the intracellular Ca2+ homeostasis play a central role in the pathophysiology of neurodegenerative diseases such as Alzheimer and Parkinson. Channel blockers may be effective in neurodegenerative diseases. In this review, we aimed to review the relationship between the metabolism of neurodegenerative diseases and Ca2+ dyshomeostasis and to reveal natural compounds, which have therapeutic effects in neurodegenerative diseases, with modulation of Ca2+ homeostasis. Evolution of their potentials for drug candidates represents an important step for the prevention of neurodegeneration and for molecular mechanisms of Ca2+ homeostasis disorders.
Keywords : Neurodegenerative Diseases, Calcium Homeostasis, Calcium Channel, Blockers

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