Homocysteine Levels in Patients with Hemorrhagic Stroke

Authors : Aysu YETİŞ, Asuman ÇELİKBİLEK, Aysel KAYA TEKEŞİN, Orhan YAĞIZ
Pages : 101-105
Doi:10.46332/aemj.1069981
View : 62 | Download : 10
Publication Date : 2023-04-16
Article Type : Research Paper
Abstract :Purpose: Accumulating data demonstrated that raised homocysteine is a risk factor for ischemic stroke. However, it remains unclear whether high homocysteine level is also a risk factor for hemorrhagic stroke, which accounts for about one-fifth of stroke patients. Our aim was to measure the plasma homocysteine levels in patients with hemorrhagic stroke to explore a possible link. Materıals and Methods: We included thirty patients with ischemic stroke, thirty patients with hemorrhagic stroke, and thirty healthy volunteers. All participants were examined for traditional risk factors and levels of folic acid, homocysteine, and vitamin B12. Results: Hypertension was higher in both ischemic stroke and hemorrhagic stroke patients than in healthy participants insert ignore into journalissuearticles values(p=0.029);. Homocysteine levels were significantly higher in both ischemic stroke and hemorrhagic stroke groups than in the control group insert ignore into journalissuearticles values(p=0.001);, with no statistically difference between each other insert ignore into journalissuearticles values(p>0.05);. Vitamin B12 levels were significantly lower in both ischemic stroke and hemorrhagic stroke patients than in the controls insert ignore into journalissuearticles values(p=0.001);, with no statistically difference between each other insert ignore into journalissuearticles values(p>0.05);. Folic acid levels did not significantly differ between the groups insert ignore into journalissuearticles values(p>0.05);. We did not find correlation between homocysteine, vitamin B12 and folic acid levels insert ignore into journalissuearticles values(p>0.05);. Conclusion: Our study indicated that the homocysteine levels were high in patients with hemorrhagic stroke. Larger cohorts are needed to clarify the role of homocysteine in hemorrhagic stroke.
Keywords : hemorajik inme, homosistein, folik asit, B12 vitamini

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