The Role of Dynamic Susceptibility Contrast Perfusion Magnetic Resonance Imaging in the Evaluation of Active and Inactive Demyelinating Plaques in Multiple Sclerosis

Authors : Seyit Erol, Hakan Cebeci

Pages : 442-446

Doi:10.54005/geneltip.1599021

View : 38 | Download : 28

Publication Date : 2025-06-30

Article Type : Research Paper

Abstract :Background Our goal in this study was to find out if active plaques that exhibit enhancement and inactive plaques that do not differ in DSC-PWI measures in MS patients. Material and Methods: In our study, Dynamic susceptibility contrast perfusion-weighted MRI (DSC-PI) examinations of 30 patients diagnosed with Multiple Sclerosis were retrospectively analyzed. A region of interest (ROI) was manually drawn on DSC-PI between active plaques that showed enhancement on conventional MRI sequences and inactive plaques that did not show enhancement. Cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) in this ROI were also recorded. These measurements were also normalized to apparently unaffected contralateral white matter hemisphere measurements. These normalized values were named rCBV, rCBF, rMTT and rTTP. Results: Both rCBV and rCBF were significantly higher in active demyelinating plaques compared to chronic demyelinating plaques (p<0.001). Mean rCBV and rCBF values in active plaques were 1.61 ± 0.66 and 1.44 ± 0.59, respectively. In chronic plaques, mean rCBV was 0.91 ± 0.32 and mean rCBF was 0.81 ± 0.26. The mean rMTT was 0.98 ± 0.53 in active demyelinating plaques and 1.30 ± 0.44 in chronic demyelinating plaques and there was a significant difference between the two groups (p=0.004). Mean rTTP was also significantly prolonged in active demyelinating plaques compared to chronic plaques (p<0.001). Mean rTTP was 0.93 ± 0.14 and 1.06 ± 0.21 in active and chronic demyelinating plaques, respectively Conclusions: In conclusion, DSC-PI examination may provide reliable information in the evaluation of active and inactive demyelinating plaques in MS.
Keywords : Multipl Skleroz, Manyetik Rezonans Görüntüleme, Demyelinizan hastalık

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