Evaluating the Uric Acid/Albumin Ratio as a Biomarker for Disease Severity in Acute Myocarditis Patients

Authors : Hatice Eyiol, Azmi Eyiol, Ahmet Taha Şahin

Pages : 922-933

Doi:10.54005/geneltip.1677988

View : 145 | Download : 235

Publication Date : 2025-10-28

Article Type : Research Paper

Abstract :ABSTRACT Aim Uric acid/albumin ratio (UAR) has recently emerged as a potential marker for oxidative stress and inflammation, which are key components in the pathophysiology of myocarditis. Therefore, high UAR may reflect increased disease activity and severity in myocarditis patients. In this study, we aimed to evaluate the usability of uric acid/albumin ratio as a biomarker in determining disease severity in patients with acute myocarditis. Methods The study population was evaluated retrospectively. Laboratory parameters of the patients were examined. We classified the condition as severe myocarditis based on the presence of refractory chest pain, hypotension, detection of pericardial effusion with subsequent increase, a decrease in ejection fraction (EF), and lack of response to medical and symptomatic treatment. The primary outcome was the association between UAR and disease severity. Results The median age was 43.5 years. The UAR was significantly higher in females (0.10 vs. 0.10, p=0.003). Patients with pericardial effusion had significantly higher UARs (0.137 vs. 0.100, p<0.001), and those requiring intensive therapies such as inotropes, IV steroids, or IVIG also showed elevated UARs. Conclusion Our study provides evidence supporting the use of UAR as a novel marker for assessing disease severity in acute myocarditis patients. By integrating markers of oxidative stress and nutritional/inflammatory status, UAR offers a comprehensive tool for risk stratification and management in clinical practice
Keywords : Miyokardit, Ürik asit/ Albümin oranı, Perikardial effüzyon

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