Melatonin prevented depressive-like behavior following cyclosporine A or interferon-α administration in mice

Authors : Azadeh MESRİPOUR, Mahdi AGHAMOHSENİ

Pages : 209-217

Doi:10.52794/hujpharm.1061875

View : 41 | Download : 13

Publication Date : 2022-12-01

Article Type : Research Paper

Abstract :Cyclosporine A insert ignore into journalissuearticles values(CYA); is prescribed to prevent graft rejection after transplantation. Interferon-α insert ignore into journalissuearticles values(IFN-α);, a natural cytokine, is prescribed for some types of malignancies, and hepatitis C virus. But both may cause neurologic complications such as depression following their chronic use. Melatonin is a hormone that helps regulate the circadian rhythm, additionally the melatonin system is connected to depression. The goal was evaluating the antidepressant effect of melatonin following IFN-α, and CYA administration in mice. Male NMRI mice insert ignore into journalissuearticles values(25-30 g); were used, IFN-α insert ignore into journalissuearticles values(1600000 IU/kg, sc);, CYA insert ignore into journalissuearticles values(20 mg/kg, ip);, melatonin insert ignore into journalissuearticles values(50 mg/kg, ip);, and fluoxetine insert ignore into journalissuearticles values(20 mg/kg, ip); were administered daily. After evaluating the locomotor activity, depression was assessed by splash test, forced swimming test insert ignore into journalissuearticles values(FST);, and the sucrose preference test. There was no significant difference in the locomotor activity amongest different animal groups. Follow- ing melatonin and IFN-α co-administration immobility time in FST decreased insert ignore into journalissuearticles values(58.50±19.4s, p<0.01);; and during the splash test grooming time increased significantly insert ignore into journalissuearticles values(114.3±15.3s, p<0.01); compared to the IFN-α alone group, and sucrose preference rose up to 70%. After melatonin and CYA co-administration immobility time during FST decreased insert ignore into journalissuearticles values(42.33±9.9s, p<0.001);; and grooming time increased significantly insert ignore into journalissuearticles values(103±10.5s, p<0.001); compared to the CYA alone group, sucrose preference also increased up to 93%. The changes induced by melatonin in these experiments were similar to changes made by fluoxetine. Melatonin prevented depression behavior insert ignore into journalissuearticles values(despair, apathy, and anhedonia); induced by IFN-α, or CYA in mice. The mechanism involved in melatonin antidepressant-like effect warrants further investigations.
Keywords : depression, cyclosporine A, interferone alfa, melatonin, animal model

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