USE OF INFLAMMATORY MARKERS IN THE DIAGNOSIS OF ECTOPIC PREGNANCY

Authors : Murat Polat, Mehmet Alican Sapmaz, Sait Erbey, Furkan Akın
Pages : 493-498
Doi:10.38136/jgon.1787533
View : 60 | Download : 107
Publication Date : 2026-01-03
Article Type : Research Paper
Abstract :Background: This study aimed to evaluate the utility of inflammatory markers, including the systemic immune-inflammation index, systemic inflammatory response index, and pan-immune inflammatory value, in diagnosing ectopic pregnancy. Methods: A retrospective analysis was conducted on 105 patients diagnosed with ectopic pregnancy and 105 patients with intrauterine pregnancies treated at our hospital between November 2022 and September 2023. Ectopic pregnancy diagnoses were confirmed through ultrasonography. Data collected included age, gravida, parity, white blood cell count, neutrophil count, monocyte count, lymphocyte count, and platelet count. The inflammatory markers were calculated and compared between the groups using statistical software. Results: Significant differences were observed in white blood cell, neutrophil, monocyte, and lymphocyte counts. The systemic immune-inflammation index values were significantly higher in the ectopic pregnancy group (890.70±545.30) compared to the intrauterine pregnancy group (1121.50±537.59, p=0.004). Similarly, the systemic inflammatory response index and pan-immune inflammatory value were significantly elevated in the ectopic pregnancy group (systemic inflammatory response index: 70.31±29.70 vs. 89.07±32.49, p=0.000; pan-immune inflammatory value: 477.56±270.08 vs. 679.77±319.18, p=0.000). Receiver operating characteristic curve analysis showed moderate diagnostic accuracy for these markers with area under the curve values of 0.670, 0.670, and 0.710, respectively. Conclusions: Inflammatory markers such as the systemic immune-inflammation index, systemic inflammatory response index, and pan-immune inflammatory value show potential as diagnostic tools for ectopic pregnancy. Incorporating these markers into clinical practice could improve diagnostic accuracy, complementing traditional methods. Further research with larger sample sizes is required to validate these findings and enhance their clinical application.
Keywords : Ektopik Gebelik, Biyobelirteçler, Enflamasyon, Bağışıklık Sistemi

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