The Role of Monocyte Count and Monocyte Based Complete Blood Cell Indexes in Predicting the Development, Severity and Prognosis of Intrahepatic Cholestasis of Pregnancy in the First Trimester

Authors : Bedri Sakcak, Ramazan Denizli, Nihat Farisoğullari, Zahid Ağaoğlu, Atakan Tanacan, Dilek Sahin

Pages : 1982-1989

Doi:10.38136/jgon.1289766

View : 110 | Download : 70

Publication Date : 2023-12-31

Article Type : Research Paper

Abstract :Abstract Aim: To evaluate the effect of monocyte count and monocyte-based whole blood cell indices in the prediction of intrahepatic cholestasis of pregnancy (ICP) in the first trimester. Materials and Method: The clinical data of patients who presented to the Perinatology Clinic of the Turkish Ministry of Health ----xxxxxxx--- ICP between January 1, 2021, and October 1, 2022, were evaluated retrospectively. Maternal demographic parameters, gestational age at birth, fetal birth weight, first-trimester white blood cell, neutrophil, platelet, monocyte, lymphocyte, and basophil counts, lymphocyte-to-monocyte ratio (LMR), platelet-to-monocyte ratio (PMR), neutrophil-to-monocyte ratio (NMR), and basophil-to-monocyte ratio (BMR) were recorded. These parameters were compared between the ICP and control groups. The relationship between monocyte count, monocyte-based blood cell indices, and fasting bile acid levels was evaluated in the ICP group. The cut-off values of the first-trimester monocyte count and monocyte-based blood cell indices for the prediction of ICP were determined. Results: Gestational week at birth and fetal birth weight were significantly lower, and the neonatal intensive care requirement was significantly higher in the ICP group (p<0.05) compared to the control group. The ICP group had a significantly higher monocyte count (p=0.002), a significantly lower platelet count (p=0.002), and significantly lower values for monocyte-based complete blood cell indices (NMR, LMR, and PMR) compared to the control group (p=0.005, p=0.001, and p<0.001, respectively). Conclusion: A high monocyte count and low monocyte-based inflammatory indices measured in the first trimester of pregnancy seem to be associated with ICP. These novel indices can be used in the prediction of ICP and its adverse perinatal outcomes.
Keywords : gebelik, intrahepatik kolestaz, monosit, serum safra asidi

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