Assessment of antioxidant, skin whitening and anti-Alzheimer effects of Ferulago asparagifolia Boiss.

Authors : Yavuz Bağcı, Tuğsen Büyükyıldırım, Fatma Ayaz, Nuraniye Eruygur

Pages : 11-20

Doi:10.7212/karaelmasfen.1504506

View : 54 | Download : 29

Publication Date : 2025-04-22

Article Type : Review Paper

Abstract :Ferulago W. Koch is an important genus from the Apiaceae family, widely used in traditional medicine and rich in bioactive compounds. Ferulago asparagifolia Boiss. contains coumarins, terpenoids, flavonoids, and phenolic compounds. In this study, the antioxidant activities and total phenol/flavonoid content of F. asparagifolia fruit and leaf extracts were measured. The antioxidant activities were assessed using DPPH (1,1-Diphenyl-2-picrylhydrazyl), ABTS (2,2’ azinobis (3-ethylbenzothiazoline 6-sulfonic acid)), and iron chelation methods spectrophotometrically. The ethanol extract of F. asparagifolia leaves showed 58.73% DPPH radical scavenging activity at 1 mg/mL concentration, while the fruit ethanol extract exhibited 53.13% activity. In the ABTS radical scavenging activity test, all extracts showed increased activity with increasing concentrations, with leaf and fruit ethanol extracts showing 85.85% and 85.70% activity at 1 mg/mL concentration, respectively. The highest phenol content (218.78 ± 4.55 mg gallic acid equivalent (GAE)/g) was found in the ethanol extract of F. asparagifolia leaves. The anti-acetylcholinesterase (Anti-AChE) and antibutyrylcholinesterase (Anti-BuChE) activity of F. asparagifolia extracts was investigated using the Ellman method, and the anti-tyrosinase (Anti-TYR) activity was examined using the dopachrome method in vitro. The hexane extract of F. asparagifolia fruit showed significant inhibitory activity against AChE (145.1 µg/mL). Additionally, the ethanol extract of F. asparagifolia leaves exhibited the highest anti-tyrosinase activity (2.42 mg/mL). In conclusion, while F. asparagifolia extracts possess significant antioxidant activities, they also demonstrate considerable antityrosinase activity, indicating their potential use in the treatment of neurodegenerative diseases and development of skin-whitening products. Therefore, further in-depth research is warranted for F. asparagifolia to be used in oxidative stress defense or in the development of products related to its anti-tyrosinase activity.
Keywords : Antioksidan aktivite, Ferulago asparagifolia Boiss., kolinesteraz, tirozinaz

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