DIAGNOSTIC ACCURACY OF ENDOMETRIAL SAMPLING AND COLPOSCOPY GUIDED CERVICAL BIOPSY IN WOMEN UNDERGOING HYSTERECTOMY: A SINGLE-CENTER EXPERIENCE

Şeyma İlayda Paltacı; Sudaba Garibova; Rıza Dur; Mine Kanat Pektaş

doi:10.18229/kocatepetip.1522212

DIAGNOSTIC ACCURACY OF ENDOMETRIAL SAMPLING AND COLPOSCOPY GUIDED CERVICAL BIOPSY IN WOMEN UNDERGOING HYSTERECTOMY: A SINGLE-CENTER EXPERIENCE

Authors : Şeyma İlayda Paltacı, Sudaba Garibova, Rıza Dur, Mine Kanat Pektaş

Pages : 122-127

Doi:10.18229/kocatepetip.1522212

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Publication Date : 2025-04-28

Article Type : Research Paper

Abstract :OBJECTIVE: This study aims to compare the results of the preoperatively obtained endometrial and cervical biopsies to the histopathological characteristics of the related hysterectomy specimens and, thus in vestigate their consistency. MATERIAL AND METHODS: This is a retrospective review of 390 hysterectomies performed for both benign and malignant indications as verified by cervical and endometrial biopsies at the study center between 1 January 2017 and 1 January 2023. RESULTS: Seventy-four hysterectomies (19.0%) had preoperative cervical biopsy results, while 316 had preoperative endometrial biopsy results (81.0%). Only 55.6% agreement (κ=0.011) and no significant correlation between endometrial biopsy results and related hysterectomy specimens for benign lesions (χ2=4.500, p=0.343). There were 85.1% agreement (κ=0.462) and a significant correlation between cervical biopsy results and related hysterectomy specimens for pre-invasive and malignant lesions (χ2=106.349, p=0.001). Endometrial biopsy results presenting polyps had the lowest diagnostic accuracy of 59.3% and endometrial cancer was identified in 52.2% of the patients whose biopsy results revealed complex hyperplasia with atypia. CONCLUSIONS: The relatively lower diagnostic accuracy of endometrial biopsy suggests that it is not required for definitive diagnosis in patients who are scheduled to have a hysterectomy for benign indications. The relatively higher rate of complex atypical hyperplasia and endometrial cancer co-existence also indicates that hysteroscopy can be performed to visualize the uterine cavity before a hysterectomy is planned for patients with biopsy-based hyperplasia. The relatively higher concordance rate between cervical biopsy results and related hysterectomy specimens supports the significance and validity of colposcopy in the management of pre-invasive and malignant lesions of the cervix.
Keywords : Biyopsi, Teşhis, Histerektomi, Patoloji

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