The Impact of Pseudomonas aeruginosa in Sputum on the Clinical Progression of Patients with Bronchiectasis

Authors : Aslı Mezide Dulkadiroğlu, Şeyma Başlılar, Gökçe Külah, Erhan Oğur, Bengü Şaylan
Pages : 72-77
Doi:10.35514/mtd.2025.132
View : 80 | Download : 79
Publication Date : 2025-12-31
Article Type : Research Paper
Abstract :Aim: Recurrent infections and bacterial colonization of the lower respiratory tract in bronchiectasis are associated with disease progression and poor prognosis. This study aimed to investigate the impact of the existence of Pseudomonas aeruginosa (PA) in sputum on the clinical progression of patients with bronchiectasis. Materials and methods: Between October 1, 2016, and October 1, 2023, we retrospectively evaluated 220 patients diagnosed with bronchiectasis who were followed up at the chest diseases clinic and had their sputum cultures examined. Patients were divided into two groups; those with and without PA detected in the sputum (PA+ and PA -), and compared. Results: PA overgrowth was detected in 66/220 patients. Patients in PA+ group were older and used Inhaled Corticosteroids (ICS), nebulizers, Bilevel Positive Airway Pressure (BPAP), and Long-Term Oxygen Therapy (LTOT) more frequently (p= 0.024, p=0.040, p=0.010, p<0.001 and p<0.001, respectively). Pulmonary function parameters (forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC)) were lower, and intensive care unit admission and mortality rate were higher in PA+ group (p= 0.027, p= 0.036, p=0.002, p= 0.013, respectively). PA growth in sputum was postively correlated with age, ICS use, use of nebulizer, BPAP, LTOT, and intensive care unit (ICU) hospitalization while negatively correlated with FEV1 (%) value. (p=0.015, p=0.048, p=0.007, p<0.001, p<0.001, p=0.02, p=0.036) Conclusion: It was concluded that the presence of PA in sputum in patients with bronchiectasis negatively affects the clinical course and respiratory function and is associated with increased mortality.
Keywords : Bronşektazi, Mortalite, Prognoz, Pseudomonas Aeruginosa.

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