The Neurological Outcomes of Amantadine Hydrochloride in Different Etiologies of Traumatic Brain Injury

Authors : Aslı Alkan, Canan Gürsoy, Emine Kaya Çubuk, Güven Gürsoy
Pages : 264-268
Doi:10.47572/muskutd.1701099
View : 41 | Download : 120
Publication Date : 2025-12-29
Article Type : Research Paper
Abstract :Traumatic brain injury is a major public health concern associated with significant neurological sequelae and high mortality. Although its treatment is multifactorial, the effects of amantadine hydrochloride—originally developed as an antiviral agent and later identified to have neuromodulatory properties—are still under investigation. This study aimed to evaluate the impact of amantadine hydrochloride on neurological outcomes in traumatic brain injury patients with different etiologies.A total of 51 patients diagnosed with traumatic brain injury of various etiologies and monitored in the intensive care unit were retrospectively included in the study. Sociodemographic data, clinical findings, imaging results, treatment details involving amantadine hydrochloride, and follow-up Glasgow Coma Scale scores were extracted from medical records. The mean age of the patients was 43.0±21.0 years, and 76.5% were female. The most common etiologies were subarachnoid hemorrhage (37.3%) and subdural hemorrhage (19.6%). Amantadine hydrochloride was administered to 50.9% of the patients. The need for sedation and anti-edema therapy was significantly higher in the amantadine group (p<0.050). Patients receiving amantadine hydrochloride showed a statistically significant improvement in Glasgow Coma Scale scores at discharge, particularly in cases with single etiologies such as subarachnoid or subdural hemorrhage (p<0.050). Amantadine hydrochloride may support neurological recovery in traumatic brain injury patients, particularly those with isolated hemorrhagic etiologies. However, no similar benefit was observed in patients with combined subarachnoid and subdural hemorrhage. These findings suggest the need for further research to investigate the efficacy of amantadine hydrochloride across different traumatic brain injury etiologies.
Keywords : Amantadin Hidroklorür, Yoğun Bakım, Nöromodülatör, Travmatik Beyin Hasarı

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