The Role of Platelet Mass Index in Predicting Short-Term Mortality in Community-Acquired Pneumonia: An Analytical Study

Authors : Serdar Özdemir, İbrahim Altunok, Abuzer Özkan

Pages : 66-73

View : 55 | Download : 62

Publication Date : 2025-05-15

Article Type : Research Paper

Abstract :Introduction: Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide, particularly among elderly patients and those with comorbidities. Early risk stratification is crucial for optimizing treatment decisions. Platelets play a key role in hemostasis and inflammation, and platelet-related indices have been investigated as potential prognostic markers. The Platelet Mass Index (PMI), calculated as platelet count × mean platelet volume (MPV), has been proposed as a marker of inflammatory severity. This study aims to evaluate the prognostic value of PMI in predicting short-term mortality in hospitalized CAP patients. Methods: This retrospective observational study included adult patients diagnosed with CAP and hospitalized between January 1, 2023, and January 1, 2024. Demographic data, clinical parameters, laboratory findings, and severity scores (PSI, CURB-65) were collected. PMI values were compared between survivors and non-survivors. Statistical analyses included Mann-Whitney U tests, chi-square tests, and logistic regression. The predictive performance of the model was assessed using ROC curve analysis. Results: A total of 174 CAP patients (67% male, median age 77 years) were analyzed. The most common symptom was dyspnea (82%). No significant difference in PMI was observed between survivors and non-survivors (p=0.33). Higher PSI and CURB-65 scores, lower albumin levels, and elevated respiratory rates were associated with increased mortality. The predictive model for mortality demonstrated an AUC of 0.814. Conclusion: PMI was not a significant predictor of short-term mortality in hospitalized CAP patients. The inflammatory response in severe cases and potential confounders may have influenced the results. Further prospective studies in broader patient populations are needed to clarify PMI’s prognostic role.
Keywords : Toplum kökenli pnömoni, pnömoni, mortalite, trombosit, ortalama trombosit hacmi

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