Abstract :Social-emotional health is an internal resource of mental health that influences an individual`s well- being. Recently, in Vietnam, a Southeast Asian developing country, the Ministry of Education and Training directed the national digital transformation of the education sector to build well-being schools and develop intelligent digital schools to create a generation of global citizens. This context raises the need for mental health care and the promotion of students’ psychological well-being at schools. The social-emotional health framework is a research and practice orientation that has been interesting in Vietnam recently to promote the school-based well-being of children and adolescents. This paper analyzed the factors affecting the social-emotional health of Vietnamese adolescents. This is a cross-sectional study in the context of the national digital transformation in the Vietnamese education sector with solid impacts on the mental health of 600 adolescents representing three Vietnamese regions. By EFA and linear regression analysis, we discovered five groups of factors affecting the adolescents` social-emotional health, including (1) Family characteristics and community culture, (2) Individual psychological characteristics, (3) Parental education, (4) Family characteristics and structures, and (5) Personal experience and help-seeking behavior. The results expanded our understanding of factors associated with the social-emotional health of Vietnamese adolescents, in which factors of family traditions and parenting play an essential role in balancing and promoting the participants’ well-being. Meanwhile, factors related to digital technology have not had much impact on social-emotional health in adolescents. These findings are essential evidence for educational psychologists and educators to design mental health prevention or intervention programs for adolescents that focus on developing social-emotional skills. Keywords : Social-Emotional Health, Factor, Mental Health, Adolescent, Digital Educational Transformation.