Analysis of the Association of Allergic Disease in Pediatric Patients with Hereditary Angioedema

Authors : Ayşe AYDOĞDU, Ali AYDOĞDU

Pages : 321-325

Doi:10.20515/otd.1186392

View : 179 | Download : 200

Publication Date : 2023-05-23

Article Type : Research Paper

Abstract :Hereditary angioedema insert ignore into journalissuearticles values(HAE); is a rare autosomal dominant disease that is derived from the deficiency or dysfunction of C1 esterase inhibitor insert ignore into journalissuearticles values(C1-INH);. In studies about the diseases that can accompany hereditary angioedema, allergic diseases occur more frequently compared to the healthy population but no studies on this issue have been carried out. This study was conducted in order to determine the frequency of the comorbidity of atopic sensitivity and allergic diseases in patients with hereditary angioedema. 32 patients who were diagnosed with hereditary angioedema in the Paediatric Allergy Polyclinic of Mersin City Hospital between 2019 and 2021 were included in the study. In these patients, the information about the existence of atopic diseases was obtained from their files and recorded. While asthma was observed in 6 insert ignore into journalissuearticles values(18.8%);, allergic rhinitis in 18 insert ignore into journalissuearticles values(46.9%);, and urticaria in 2 insert ignore into journalissuearticles values(6.2%); patients, dermatitis was not observed in any of the patients. While Fx5 test was positive in 5 insert ignore into journalissuearticles values(15.6%); patients, inhalant allergen mix sps IgE was positive in 7 insert ignore into journalissuearticles values(25.9%); patients. The IgE value was above 100 in 12 insert ignore into journalissuearticles values(52.2%); patients, and the eosinophil level was above 4% in 16 insert ignore into journalissuearticles values(50%); patients. In conclusion, we speculate in this study that the association of atopic disease and atopic sensitivity is observed more frequently in patients with angioedema than in the healthy population. However, a study with a larger sample is necessary to confirm this finding. 
Keywords : Hereditary angioedema, allergic inflammation, bradykinin, Allergy, Bradykinin