The Role of Serum Cadmium Levels in the Etiology of Premature Ovarian Failure: A Case-Control Study

Authors : Sevil ÇİÇEK, Pınar KIRICI, Abdullah KARAER

Pages : 342-347

Doi:10.20515/otd.1190726

View : 70 | Download : 128

Publication Date : 2023-05-23

Article Type : Research Paper

Abstract :Premature ovarian failure insert ignore into journalissuearticles values(POF); is a clinical syndrome known to affect approximately 1% of women of reproductive age. A number of genetic, autoimmune, metabolic, infectious and environmental causes have been identified in the etiology of POF. Cadmium is a toxic metal which can accumulate in ovaries and causes a significant decrease in the binding of gonadotropins that regulate steroidogenic enzyme activity in granulosa cells. We aimed to investigate the role of cadmium in the etiology of POF. Thirty-five patients with POF were enrolled in group 1 which was the study group. Two control groups were formed from healthy participants. Thirty-fiveparticipants who were age-matched young women with regular menstruation were included in group 2.Thirty-fivehealthy postmenopausal women were included in group 3. Patients\` demographic data were recorded. Serum follicle-stimulating hormone insert ignore into journalissuearticles values(FSH);, luteinizing hormone insert ignore into journalissuearticles values(LH);, estradiol insert ignore into journalissuearticles values(E2);, thyroid-stimulating hormone insert ignore into journalissuearticles values(TSH);, triiodothyronine insert ignore into journalissuearticles values(T3);, thyroxine insert ignore into journalissuearticles values(T4); and cadmium levels were measured. There was a statistically significant difference between the groups for gravida, parity and living children insert ignore into journalissuearticles values(p<0.001);, but no difference was found for abortion insert ignore into journalissuearticles values(p=0.430);. While there was a statistically significant difference between the groups for serum FSH, LH and E2 levels insert ignore into journalissuearticles values(p<0.001);, no statistically significant difference was found for T3, T4 and TSH. Serum cadmium levels were found to be statistically significantly decreased in group 1 compared to g roups 2 and 3 insert ignore into journalissuearticles values(p<0.001);. This study revealed that cadmium had no direct effect on the development of POF, but it should be kept in mind that the synergistic and antagonistic effects of metals may affect this result.
Keywords : Kadmiyum, Ağır metal maruziyeti, İnfertilite, Prematür ovaryan yetmezlik