Effects of Inhalation Anesthetics on Respiratory Mechanics

Authors : Burak Erken, Fatiş Altıntaş, Tuğhan Utku, Pınar Kendigelen, Çiğdem Tütüncü, Birsel Ekici, Şafak Emre Erbabacan, Aylin Nizamoğlu, Cigdem Akyol Beyoglu, Güniz Meyancı, Güner Kaya

Pages : 567-575

Doi:10.20515/otd.1661114

View : 47 | Download : 14

Publication Date : 2025-06-18

Article Type : Research Paper

Abstract :This study aimed to compare the effects of sevoflurane and desflurane on respiratory mechanics during general anesthesia in pediatric patients with respiratory problems. This prospective, randomized study included 40 pediatric patients (6 girls and 34 boys), aged 1-6 years, who underwent elective lower urinary tract surgery (e.g., orchiopexy and hypospadias repair) under general anesthesia at our university hospital between February 1, 2015, and May 1, 2015. Patients were assigned to two groups based on the administered inhalation agent: sevoflurane or desflurane. Airway resistance (RAW), dynamic compliance (Cdyn), peak inspiratory pressure (PIP), and plateau pressure (Pplato) were measured at multiple time points during general anesthesia at 1, 3, 6, 10, 15, 20, 30, 40, 60, 90, 120 min and after intubation. The values were then compared between the groups There were no statistically significant differences between the sevoflurane and desflurane groups regarding RAW, Cdyn, PIP, and Pplato values (p> 0.05). Sevoflurane and desflurane are both viable options for maintaining general anesthesia in children with RADS. However, additional studies are required to identify the safest anesthetic agents, especially in pediatric patients with underlying respiratory issues.
Keywords : reaktif hava yolu disfonksiyon sendromu, solunum mekanikleri, inhalasyon anestezikleri, sevofluran, desfluran

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