Preoperative Immunonutritional Scores as Predictors of Mortality and Recurrence in Patients with Peritoneal Carcinomatosis Secondary to Serous Ovarian Cancer Undergoing Cytoreductive Surgery and HIPEC

Authors : Yavuz Selim Angın, Orkhan Ulfanov, Elçin Telli, Elif Gündoğdu, Cengiz Ceylan, Akile Zengin, Mehmet Kılıç, Murat Ulaş

Pages : 900-907

Doi:10.20515/otd.1744552

View : 62 | Download : 75

Publication Date : 2025-09-26

Article Type : Research Paper

Abstract :Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with cytoreductive surgery (CRS) has become an increasingly preferred treatment for women with ovarian cancer presenting with peritoneal involvement. However, due to the high morbidity of HIPEC, accurate preoperative patient selection is essential. This study aimed to evaluate the prognostic value of immunonutritional indices—CALLY (C-reactive protein, albumin, lymphocyte) and Prognostic Nutritional Index (PNI)—in predicting early mortality and recurrence in patients undergoing CRS and HIPEC. A retrospective analysis was conducted on 49 female patients. Low CALLY (<0.55) and PNI (<49) values were significantly associated with worse early mortality and disease-free survival (DFS). In receiver operating characteristic (ROC) analyses, CALLY and PNI showed strong predictive power with AUC values of 0.882 and 0.914, respectively. Kaplan-Meier survival curves demonstrated significantly reduced 3- and 6-month survival rates in patients with low scores.In conclusion, CALLY and PNI are easy-to-calculate, cost-effective, and clinically practical biomarkers that may improve patient selection for CRS and HIPEC and support the development of personalized perioperative care protocols.
Keywords : Over kanseri, Sitoredüksiyon, HİPEK, Peritoneal karsinmatoz, İmmünonutriyonel skorlar, CALLY.

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